This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Endothelium plays a fundamental role in the cardiovascular system, forming an interface
between blood and adjacent tissues by regulating the vascular tone through the synthesis of …

Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …

Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where
blood flow pattern is disturbed rather than being laminar, and wall shear stress has an …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

The shear-responsive transcription factor Krüppel-like factor 2 (KLF2) is a critical regulator of
endothelial gene expression patterns induced by atheroprotective flow. As microRNAs …

Atherosclerosis represents a significant cause of morbidity and mortality in both the
developed and developing countries. Animal models of atherosclerosis have served as …

Atherosclerosis preferentially occurs in arterial regions exposed to disturbed flow, in part,
due to alterations in gene expression. MicroRNAs (miRNAs) are small, noncoding genes …

Cardiac exosomes mediate cell-to-cell communication, stimulate or inhibit the activities of
target cells, and affect myocardial hypertrophy, injury and infarction, ventricular remodeling …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …