Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit

SL McGee, M Hargreaves - Nature Reviews Endocrinology, 2020 - nature.com
Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

Inactivity and skeletal muscle metabolism: a vicious cycle in old age

E Rezuş, A Burlui, A Cardoneanu, C Rezuş… - International journal of …, 2020 - mdpi.com
Aging is an inevitable and gradually progressive process affecting all organs and systems.
The musculoskeletal system makes no exception, elderly exhibit an increased risk of …

Genetic and epigenetic sex-specific adaptations to endurance exercise

S Landen, S Voisin, JM Craig, SL McGee, S Lamon… - Epigenetics, 2019 - Taylor & Francis
In recent years, the interest in personalised interventions such as medicine, nutrition, and
exercise is rapidly rising to maximize health outcomes and ensure the most appropriate …

Omics and exercise: global approaches for mapping exercise biological networks

NJ Hoffman - Cold Spring Harbor perspectives in …, 2017 - perspectivesinmedicine.cshlp.org
The application of global “-omics” technologies to exercise has introduced new opportunities
to map the complexity and interconnectedness of biological networks underlying the tissue …

A Circular RNA Generated from Nebulin (NEB) Gene Splicing Promotes Skeletal Muscle Myogenesis in Cattle as Detected by a Multi‐Omics Approach

K Huang, Z Li, D Zhong, Y Yang, X Yan… - Advanced …, 2024 - Wiley Online Library
Cattle and the draught force provided by its skeletal muscle have been integral to agro‐
ecosystems of agricultural civilization for millennia. However, relatively little is known about …

Histone deacetylases as modulators of the crosstalk between skeletal muscle and other organs

A Renzini, M D'onghia, D Coletti, V Moresi - Frontiers in physiology, 2022 - frontiersin.org
Skeletal muscle plays a major role in controlling body mass and metabolism: it is the most
abundant tissue of the body and a major source of humoral factors; in addition, it is primarily …

The Landscape of Accessible chromatin and developmental transcriptome maps reveal a genetic mechanism of skeletal muscle development in pigs

L Feng, J Si, J Yue, M Zhao, W Qi, S Zhu, J Mo… - International Journal of …, 2023 - mdpi.com
The epigenetic regulation mechanism of porcine skeletal muscle development relies on the
openness of chromatin and is also precisely regulated by transcriptional machinery …

Molecular characterization and induced changes of histone acetyltransferases in the tick Haemaphysalis longicornis in response to cold stress

T Pei, M Zhang, Z Gao, L Li, Z Bing, J Meng… - Parasites & …, 2024 - Springer
Background Epigenetic modifications of histones play important roles in the response of
eukaryotic organisms to environmental stress. However, many histone acetyltransferases …

Trichostatin A regulates fibro/adipogenic progenitor adipogenesis epigenetically and reduces rotator cuff muscle fatty infiltration

X Liu, M Liu, L Lee, M Davies, Z Wang… - Journal of …, 2021 - Wiley Online Library
Rotator cuff (RC) muscle fatty infiltration (FI) is an important factor that determines the clinical
outcome of patients with RC repair. There is no effective treatment for RC muscle FI at this …

Methylome and proteome integration in human skeletal muscle uncover group and individual responses to high-intensity interval training.

M Jacques, S Landen, JA Romero, D Hiam… - The FASEB …, 2023 - vuir.vu.edu.au
Exercise is a major beneficial contributor to muscle metabolism, and health benefits
acquired by exercise are a result of molecular shifts occurring across multiple molecular …