Over the last decade, liquid biopsy has gained much attention as a powerful tool in
personalized medicine, since it enables monitoring cancer evolution and follow-up of cancer …

Cutaneous melanoma is a lethal disease, even when diagnosed in advanced stages.
Although recent progress in biology and treatment has dramatically improved survival rates …

Purpose: Liquid biopsy provides real-time monitoring of tumor evolution and response to
therapy through analysis of circulating tumor cells (CTCs) and plasma-circulating tumor DNA …

Optimal treatment of brain metastases is often hindered by limitations in diagnostic
capabilities. To meet this challenge, here we profile DNA methylomes of the three most …

In recent years, considerable advances have been made in the characterization of protein-
coding alterations involved in the pathogenesis of melanoma. However, despite their …

We characterized the mutational landscape of human skin cutaneous melanoma (SKCM)
using data obtained from The Cancer Genome Atlas (TCGA) project. We analyzed next …

Tumor growth is the result of the interplay of complex biological processes in huge numbers
of individual cells living in changing environments. Effective simple mathematical laws have …

Tumor progression to invasive carcinoma is associated with activation of SRC family kinase
(SRC, YES, FYN) activity and loss of cellular cohesion. The hippo pathway-regulated …

Analogous to life on earth, tumor cells evolve through space and time and adapt to different
micro-environmental conditions. As a result, tumors are composed of millions of genetically …

Simple Summary Pronounced differences across individuals (interpatient variability) and cell–
cell heterogeneity within a tumor (intratumoral heterogeneity) severely hinder effective brain …