Retinoblastoma is a paediatric ocular tumour that continues to reveal much about the
genetic basis of cancer development. Study of genomic aberrations in retinoblastoma …

The nuclear pore complex (NPC) mediates trafficking between the cytoplasm and
nucleoplasm. It also plays key roles in other nuclear processes such as chromatin silencing …

Cancer genome characterization has revealed driver mutations in genes that govern
ubiquitylation; however, the mechanisms by which these alterations promote tumorigenesis …

Cancer-initiating cells (CICs) represent a relatively rare subpopulation of cells endowed with
self-renewal, stemness properties, tumorigenicity in immunodeficient mice, and resistance to …

We lack a holistic understanding of the genetic programs orchestrating embryonic colon
morphogenesis and governing damage response in the adult. A window into these …

Histone variant H3. 3 is deposited in chromatin at active sites, telomeres, and pericentric
heterochromatin by distinct chaperones, but the mechanisms of regulation and coordination …

NUP214 is a component of the nuclear pore complex (NPC) with a key role in protein and
mRNA nuclear export. Chromosomal translocations involving the NUP214 locus are …

Disease progression and recurrence are major barriers to survival for breast cancer patients.
Understanding the etiology of recurrent or metastatic breast cancer and underlying …

Chromatin is a major determinant in the regulation of virtually all DNA-dependent processes.
Chromatin architectural proteins interact with nucleosomes to modulate chromatin …

Background The DEK protein is related to chromatin reconstruction and gene transcription,
and plays an important role in cell apoptosis. High expression levels of the human DEK …