The tumor microenvironment (TME) provokes endoplasmic reticulum (ER) stress in
malignant cells and infiltrating immune populations. Sensing and responding to ER stress is …

Simple Summary Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a
multifunctional tumor suppressor with protein-and lipid-phosphatase activities. The …

BRAF is one of the most frequently mutated oncogenes, with an overall frequency of about
50%. Targeting BRAF and its effector mitogen-activated protein kinase kinase 1/2 (MEK1/2) …

Simple Summary Precision oncology is emerging as a viable option to improve survival in
patients who fail to remain disease-free even after the employment of currently available …

PTEN encodes a tumor suppressor with lipid and protein phosphatase activities whose
dysfunction has been implicated in melanomagenesis; less is known about how its …

PTEN is a well-known tumour suppressor protein that is frequently found to be mutated,
inactivated or deleted in a wide range of different cancers. Its tumour suppressive properties …

Simple Summary Around 5–10% of advanced melanoma patients progress early on anti-
BRAF targeted therapy and 20–30% respond only with the stabilization of the disease …

Leukemia stem cells (LSC) require frequent adaptation to maintain their self-renewal ability
in the face of longer exposure to cell-intrinsic and cell-extrinsic stresses. However, the …

Background This study aimed to explore the mechanism of parthenolide in inhibiting
melanoma metastasis through network pharmacology and cell experiment. Materials and …

Цель исследования. Изучение относительной копийности 12 генов: MYC, PTEN,
CCND1, PIK3CA, TP53, CDKN2A, MDM2, MCL1, NFKBIA, MTAP, BIRC2, KMT2C для …