Development of white matter hyperintensity is preceded by reduced cerebrovascular reactivity

K Sam, AP Crawley, J Conklin, J Poublanc… - Annals of …, 2016 - Wiley Online Library
Objective White matter hyperintensities (WMH) observed on neuroimaging of elderly
individuals are associated with cognitive decline and disability. However, the pathogenesis …

The relationship between cognition and cerebrovascular reactivity: implications for task-based fMRI

RJ Williams, ME MacDonald, EL Mazerolle… - Frontiers in …, 2021 - frontiersin.org
Elucidating the brain regions and networks associated with cognitive processes has been
the mainstay of task-based fMRI, under the assumption that BOLD signals are …

Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus

J Poublanc, AP Crawley, O Sobczyk… - Journal of Cerebral …, 2015 - journals.sagepub.com
We define cerebral vascular reactivity (CVR) as the ratio of the change in blood oxygen level-
dependent (BOLD) magnetic resonance imaging (MRI) signal (S) to an increase in blood …

[HTML][HTML] Comparing end-tidal CO2, respiration volume per time (RVT), and average gray matter signal for mapping cerebrovascular reactivity amplitude and delay with …

KM Zvolanek, S Moia, JN Dean, RC Stickland… - NeuroImage, 2023 - Elsevier
Cerebrovascular reactivity (CVR), defined as the cerebral blood flow response to a
vasoactive stimulus, is an imaging biomarker with demonstrated utility in a range of diseases …

Chronic ischemia alters brain microstructural integrity and cognitive performance in adult moyamoya disease

K Kazumata, KK Tha, H Narita, I Kusumi, H Shichinohe… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—The mechanisms underlying frontal lobe dysfunction in
moyamoya disease (MMD) are unknown. We aimed to determine whether chronic ischemia …

Staging hemodynamic failure with blood oxygen-level–dependent functional magnetic resonance imaging cerebrovascular reactivity: A comparison versus Gold …

J Fierstra, C van Niftrik, G Warnock, S Wegener… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Increased stroke risk correlates with hemodynamic failure, which
can be assessed with (15O-) H2O positron emission tomography (PET) cerebral blood flow …

Assessing cerebrovascular reactivity abnormality by comparison to a reference atlas

O Sobczyk, A Battisti-Charbonney… - Journal of Cerebral …, 2015 - journals.sagepub.com
Attribution of vascular pathophysiology to reductions in cerebrovascular reactivity (CVR) is
confounded by subjective assessment and the normal variation between anatomic regions …

Brain magnetic resonance imaging CO2 stress testing in adolescent postconcussion syndrome

WAC Mutch, MJ Ellis, LN Ryner, MR Graham… - Journal of …, 2016 - thejns.org
OBJECT A neuroimaging assessment tool to visualize global and regional impairments in
cerebral blood flow (CBF) and cerebrovascular responsiveness in individual patients with …

Relationship between cerebrovascular reactivity and cognition among people with risk of cognitive decline

D Kim, TM Hughes, ME Lipford, S Craft… - Frontiers in …, 2021 - frontiersin.org
Vascular risk factors (eg, obesity and hypertension) are associated with cerebral small
vessel disease, Alzheimer's disease (AD) pathology, and dementia. Reduced perfusion may …

Cerebrovascular assessment for the risk prediction of Alzheimer's disease

M Silvestrini, G Viticchi, C Altamura… - Journal of …, 2012 - content.iospress.com
Increasing evidence is emerging that vascular disease and its risk factors play a role in the
development of Alzheimer's disease (AD) and affect the probability of an adverse outcome …