Conspectus Biological membranes separate the interior of cells or cellular compartments
from their outer environments. This barrier function of membranes can be disrupted by …

Biophysical and structural investigations are presented with a focus on the membrane lipid
interactions of cationic linear antibiotic peptides such as magainin, PGLa, LL37, and melittin …

Antimicrobial peptides (AMPs), as a key component of the immune defense systems of
organisms, are a promising solution to the serious threat of drug-resistant bacteria to public …

Abstract PGLa and magainin 2 (MAG2) are amphiphilic α-helical membranolytic peptides
from frog skin with known synergistic antimicrobial activity. By systematically mutating …

Covering: up to 2020 Treatment resistance and drug-induced refractory malignancies pose
significant challenges for current chemotherapy drugs. There have been increasing …

How can highly charged, cationic antimicrobial peptides (AMPs) translocate across
hydrophobic lipid bilayers despite the prohibitive energetic penalty to do so? A common …

Every cell is protected by a semipermeable membrane. Peptides with the right properties, for
example Antimicrobial peptides (AMPs), can disrupt this protective barrier by formation of …

Magainin 2 and PGLa are cationic, amphipathic antimicrobial peptides which when added
as equimolar mixture exhibit a pronounced synergism in both their antibacterial and pore …

Biophysical and structural studies of peptide–lipid interactions, peptide topology and
dynamics have changed our view of how antimicrobial peptides insert and interact with …

Antimicrobial peptide PGLa induces the leakage of intracellular content, leading to its
bactericidal activity. However, the elementary process of PGLa-induced leakage remains …