The close relationship between hypertension and dietary sodium intake is widely
recognized and supported by several studies. A reduction in dietary sodium not only …

Background: The relationship between dietary sodium intake and blood pressure (BP) has
been tested in clinical trials and nonexperimental human studies, indicating a direct …

There is strong evidence for a causal relationship between salt intake and blood pressure.
Randomized trials demonstrate that salt reduction lowers blood pressure in both individuals …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for
enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As …

Excess reactive oxygen species production by mitochondria is a key mechanism of age-
related vascular dysfunction. Our laboratory has shown that supplementation with the …

Sodium is essential for cellular homeostasis and physiological function. Excess dietary
sodium has been linked to elevations in blood pressure (BP). Salt sensitivity of BP varies …

Sodium is an essential mineral and nutrient used in dietary practices across the world and is
important to maintain proper blood volume and blood pressure. A high sodium diet is …

Background Recent cohort studies show that salt intake below 6 g is associated with
increased mortality. These findings have not changed public recommendations to lower salt …

Chronic calorie restriction (CR) improves cardiovascular function and several other
physiological markers of healthspan. However, CR is impractical in non-obese older …