Much progress has been made toward deciphering RHO GTPase functions, and many
studies have convincingly demonstrated that altered signal transduction through RHO …

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Rho GTPases comprise a family of molecular switches that control signal transduction
pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of
Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate …

Many features of cell behavior are regulated by Rho family GTPases, but the most profound
effects of these proteins are on the actin cytoskeleton and it was these that first drew …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

A new brain serine/threonine protein kinase may be a target for the p21 ras-related proteins
Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20 …