Background Alterations in progranulin (PGRN) expression are associated with multiple
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …

Myocardial infarction (MI) induces structural and electrical cardiac remodeling in response to
ischemic insult, causing lethal arrhythmias and sudden death. Progranulin (PGRN) is a …

Since microglia-associated neuroinflammation plays a critical role in the progression of
acute spinal cord injury, modulation of microglial activation has been suggested as a …

Choroidal atrophy is a common fundus pathological change closely related to the
development of age‐related macular degeneration (AMD), retinitis pigmentosa, and …

Background. Spinal cord injury (SCI) is a devastating neurological disease characterized by
neuroinflammation and neuronal apoptosis. The PI3K/AKT signaling pathway is related to …

Background: Homozygous loss-of-function progranulin gene (GRN) mutation carriers
develop adult-onset neuronal ceroid lipofuscinosis (NCL), a lysosomal storage disease …

Progranulin (PGRN) is a secreted glycoprotein that regulates numerous cellular processes.
The role of PGRN as a regulator of lysosomes has recently received attention. The purpose …

Purpose: The laser-induced choroidal neovascularization (CNV) mouse model is the most
frequently used animal model of CNV. To test new therapeutic agents that suppress CNV …

Progranulin (PGRN) plays an important role in influenza virus infection. To gain insight into
the potential molecular mechanisms by which PGRN regulates influenza viral replication …

Nonalcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver
disease in the world. Immunity is the major contributing factor in NAFLD; however, the …