Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

At any point 1–5 days following ascent to altitudes≥ 2500 m, individuals are at risk of
developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome …

Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …

Clinical pulmonary hypertension is characterized by a sustained elevation in pulmonary
arterial pressure. Pulmonary vascular remodeling involves structural changes in the normal …

Pulmonary vascular medial hypertrophy caused by excessive pulmonary artery smooth
muscle cell (PASMC) proliferation is a major cause for the elevated pulmonary vascular …

Capacitative Ca2+ entry (CCE) through store-operated Ca2+ (SOC) channels plays an
important role in returning Ca2+ to the sarcoplasmic reticulum (SR) and regulating cytosolic …

A comprehensive update to this preeminent and accessible text, this fifth edition of a
bestseller was developed as a response to man's attempts to climb unaided to higher …

Pulmonary vascular remodelling is an important pathological feature of pulmonary
hypertension, leading to increased pulmonary vascular resistance and reduced compliance …

Hypoxia-inducible factor-1α (HIF-1α) plays an essential role in cellular and systemic O2
homeostasis by regulating the expression of genes important in glycolysis, erythropoiesis …

The pulmonary blood-gas barrier is an extraordinary bioengineering structure because of its
vast area but extreme thinness. Despite this, almost no attention has been given to its …