Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells

U Testa, G Castelli, E Pelosi - Cancers, 2018 - mdpi.com
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Non-small-cell lung cancers: a heterogeneous set of diseases

Z Chen, CM Fillmore, PS Hammerman, CF Kim… - Nature Reviews …, 2014 - nature.com
Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have
diverse pathological features. During the past decade, in-depth analyses of lung cancer …

Decellularized matrices in regenerative medicine

DA Taylor, LC Sampaio, Z Ferdous, AS Gobin, LJ Taite - Acta biomaterialia, 2018 - Elsevier
Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a
promising tool used either alone or when combined with other biologics in the fields of tissue …

Alveolar progenitor and stem cells in lung development, renewal and cancer

TJ Desai, DG Brownfield, MA Krasnow - Nature, 2014 - nature.com
Alveoli are gas-exchange sacs lined by squamous alveolar type (AT) 1 cells and cuboidal,
surfactant-secreting AT2 cells. Classical studies suggested that AT1 arise from AT2 cells, but …

The acute respiratory distress syndrome

MA Matthay, LB Ware… - The Journal of clinical …, 2012 - Am Soc Clin Investig
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can …

Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection

PA Kumar, Y Hu, Y Yamamoto, NB Hoe, TS Wei, D Mu… - Cell, 2011 - cell.com
The extent of lung regeneration following catastrophic damage and the potential role of adult
stem cells in such a process remains obscure. Sublethal infection of mice with an H1N1 …

Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models

V Bahl, S Lin, N Xu, B Davis, Y Wang, P Talbot - Reproductive toxicology, 2012 - Elsevier
Electronic cigarettes (EC) and refill fluids are distributed with little information on their pre-
and postnatal health effects. This study compares the cytotoxicity of EC refill fluids using …

Senescence in COPD and its comorbidities

PJ Barnes - Annual review of physiology, 2017 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is regarded as a disease of accelerated
lung aging. This affliction shows all of the hallmarks of aging, including telomere shortening …

[HTML][HTML] Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization

BS Ding, DJ Nolan, P Guo, AO Babazadeh, Z Cao… - Cell, 2011 - cell.com
To identify pathways involved in adult lung regeneration, we employ a unilateral
pneumonectomy (PNX) model that promotes regenerative alveolarization in the remaining …

[HTML][HTML] Molecular heterogeneity in lung cancer: from mechanisms of origin to clinical implications

FZ Marino, R Bianco, M Accardo, A Ronchi… - … journal of medical …, 2019 - ncbi.nlm.nih.gov
Molecular heterogeneity is a frequent event in cancer responsible of several critical issues in
diagnosis and treatment of oncologic patients. Lung tumours are characterized by high …