Nanomaterial-based electrochemical sensors and biosensors for the detection of pharmaceutical compounds

L Qian, S Durairaj, S Prins, A Chen - Biosensors and Bioelectronics, 2021 - Elsevier
The surging growth of the pharmaceutical industry is a result of the rapidly increasing human
population, which has inevitably led to new biomedical and environmental issues. Aside …

Accelerating metabolite identification in natural product research: toward an ideal combination of liquid chromatography–high-resolution tandem mass spectrometry …

JL Wolfender, JM Nuzillard, JJJ Van Der Hooft… - Analytical …, 2018 - ACS Publications
Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …

Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery

S Bertrand, N Bohni, S Schnee, O Schumpp… - Biotechnology …, 2014 - Elsevier
Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …

Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?

J Hubert, JM Nuzillard, JH Renault - Phytochemistry Reviews, 2017 - Springer
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …

Natural product isolation–how to get from biological material to pure compounds

F Bucar, A Wube, M Schmid - Natural product reports, 2013 - pubs.rsc.org
Covering: 2008 to 2012Since the last comprehensive review by Otto Sticher on natural
product isolation in NPR (O. Sticher, Nat. Prod. Rep., 2008, 25, 517), a plethora of new …

Dereplication: racing to speed up the natural products discovery process

SP Gaudêncio, F Pereira - Natural product reports, 2015 - pubs.rsc.org
Covering: 1993–2014 (July) To alleviate the dereplication holdup, which is a major
bottleneck in natural products discovery, scientists have been conducting their research …

Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach

G Brusotti, I Cesari, A Dentamaro… - … of pharmaceutical and …, 2014 - Elsevier
The phytochemical research based on ethnopharmacology is considered an effective
approach in the discovery of novel chemicals entities with potential as drug leads …

Characterization of proteins by size-exclusion chromatography coupled to multi-angle light scattering (SEC-MALS)

D Some, H Amartely, A Tsadok… - JoVE (Journal of Visualized …, 2019 - jove.com
Analytical size-exclusion chromatography (SEC), commonly used for the determination of
the molecular weight of proteins and protein-protein complexes in solution, is a relative …

Recent advances and trends in the liquid-chromatography–mass spectrometry analysis of flavonoids

A de Villiers, P Venter, H Pasch - Journal of Chromatography A, 2016 - Elsevier
Flavonoids have elicited significant attention as a result of their importance in plants, their
influence on the properties of natural-product derived commodities and especially as a …

Plant metabolomics: from holistic data to relevant biomarkers

JL Wolfender, S Rudaz, Y Hae Choi… - Current medicinal …, 2013 - ingentaconnect.com
Metabolomics is playing an increasingly important role in plant science. It aims at the
comprehensive analysis of the plant metabolome which consists both of primary and …