Macrocyclic compounds useful as inhibitors of kinases and HSP90

N Winssinger, S Barluenga, M Karplus - US Patent 8,067,412, 2011 - Google Patents
2008-02-13 Assigned to UNIVERSITE LOUIS PASTEUR DE STRASBOURG, LE CENTER
NATIONAL DE LA RECHERCHE SCIENTIFIQUE reassignment UNIVERSITE LOUIS …

Therapeutic antibodies against ROR-1 protein and methods for use of same

TJ Kipps, IIGF Widhopf, B Cui - US Patent 9,933,434, 2018 - Google Patents
Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells
(particularly leukemic and lymphomic cells) and pharmaceutical compositions containing …

Macrocyclic compounds useful as inhibitors of kinases and HSP90

N Winssinger, S Barluenga, M Karplus - US Patent 8,450,305, 2013 - Google Patents
Disclosed are macrocyclic compounds of formulae IV, which are analogs of the pochonin
resorcylic acid lactones, and processes for the preparation of the compounds. The …

Reagents, methods, and systems for detecting methicillin-resistant Staphylococcus

C Cote, QX Zheng, V Shyamala, T Hazel - US Patent 8,735,554, 2014 - Google Patents
The present invention provides PBP2a peptide antigens for generating antibodies against
MRSA, and provides high-af finity binding agents that detect MRSA by selective immu …

Therapeutic antibodies against ROR-1 protein and methods for use of same

TJ Kipps, IIGF Widhopf, B Cui - US Patent 10,627,409, 2020 - Google Patents
5,639,641 A 5,776,456 A 5,783,184 A 5,830,470 A 5,830,663 A 5,837,243 A 5,843,749 A
5,861,155 A 5,969,107 A 5,977,316 A 6,080,588 A 6,291,208 B1 6,309,636 B1 6,323,027 …

Therapeutic antibodies against ROR-1 protein and methods for use of same

TJ Kipps, IIGF Widhopf, B Cui - US Patent 9,523,695, 2016 - Google Patents
Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells
(particularly leukemic and lymphomic cells) and pharmaceutical compositions containing …

标记的hsp90 抑制剂的用途

加布里拉, 奇奥斯, 那加瓦拉基肖尔, 佩拉塞提, 詹森… - 2018 - Google Patents
The invention concerns various methods of using labeled HSP90 inhibitors to improve
treatment of cancer patients with HSP90 inhibitors, including ex vivo and in vivo methods for …

Inhibitors of extracellular HSP90

DG Jay, BK Eustace, T Sakurai - US Patent 8,529,891, 2013 - Google Patents
The present invention describes inhibitors of extracellular Hsp90. The inhibition of
extracellular Hsp90 leads to a reduc tion of the invasiveness of the tumor cells. Furthermore …

Therapeutic compounds and their use in treating diseases and disorders

AC Bajji, SH Kim, R Tangallapally, B Markovitz… - 2009 - Google Patents
FDDXEJWGEMZKBX-UHFFFAOYSA-N CC (C)(C) OC (N1CCC (CC [n] 2c (Sc (c (C= O) c3)
cc4c3OCO4) nc3c (N) ncnc23) CC1)= O Chemical compound CC (C)(C) OC (N1CCC (CC …

Therapeutic antibodies against ROR-1 protein and methods for use of same

TJ Kipps, IIGF Widhopf, B Cui - US Patent 10,900,973, 2021 - Google Patents
Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells
(particularly leukemic and lymphomic cells) and pharmaceutical compositions contain ing …