Autism spectrum disorder (ASD) is a neurodevelopmental condition of heterogeneous etiology. While it is widely recognized that genetic and environmental factors and their …
Autism spectrum disorder (ASD) is one the most disabling developmental disorders, imposing an extremely high economic burden. Obtaining as accurate prevalence estimates …
Whole exome sequencing has proven to be a powerful tool for understanding the genetic architecture of human disease. Here we apply it to more than 2,500 simplex families, each …
The genetic etiology of autism spectrum disorder (ASD) is multifactorial, but how combinations of genetic factors determine risk is unclear. In a large family sample, we show …
C Wang, H Geng, W Liu, G Zhang - Medicine, 2017 - journals.lww.com
Background: The aim of this meta-analysis was to investigate the prenatal, perinatal, and postnatal risk factors for children autism. Methods: PubMed, Embase, Web of Science were …
Mutations generate sequence diversity and provide a substrate for selection. The rate of de novo mutations is therefore of major importance to evolution. Here we conduct a study of …
S Wu, F Wu, Y Ding, J Hou, J Bi… - Acta Psychiatrica …, 2017 - Wiley Online Library
Objective Advanced parental age has raised additional concern as a risk factor of autism. We conducted a meta‐analysis of observational studies investigating the association …
ABSTRACT STUDY QUESTION How has the mean paternal age in the USA changed over the past 4 decades? SUMMARY ANSWER The age at which men are fathering children in …
W Mandy, MC Lai - Journal of Child Psychology and Psychiatry, 2016 - Wiley Online Library
Background Although autism spectrum condition (ASC) is strongly genetic in origin, accumulating evidence points to the critical roles of various environmental influences on its …