Melatonin and the skeleton

AK Amstrup, T Sikjaer, L Mosekilde… - Osteoporosis …, 2013 - Springer
Melatonin may affect bone metabolism through bone anabolic as well as antiresorptive
effects. An age-related decrease in peak melatonin levels at nighttime is well documented …

Circadian disruption, melatonin rhythm perturbations and their contributions to chaotic physiology

RJ Reiter, S Rosales-Corral, R Sharma - Advances in medical sciences, 2020 - Elsevier
The aim of this report is to summarize the data documenting the vital nature of well-regulated
cellular and organismal circadian rhythms, which are also reflected in a stable melatonin …

Melatonin ameliorates nonalcoholic fatty liver induced by high‐fat diet in rats

M Pan, YL Song, JM Xu, HZ Gan - Journal of pineal research, 2006 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized condition that may
progress to end‐stage liver disease, which ranges from simple steatosis to steatohepatitis …

Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats

A Agil, M El‐Hammadi… - Journal of pineal …, 2015 - Wiley Online Library
Hepatic mitochondrial dysfunction is thought to play a role in the development of liver
steatosis and insulin resistance, which are both common characteristics of obesity and type …

Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in …

I Baeza, J Fdez-Tresguerres, C Ariznavarreta… - Biogerontology, 2010 - Springer
Ovariectomy constitutes a commonly used model in rats and mice for human menopause.
After ovariectomy, an imbalance between oxidant production and antioxidant levels appears …

Protective role of melatonin in cyclosporine A-induced oxidative stress in rat liver

R Rezzani, B Buffoli, L Rodella, A Stacchiotti… - International …, 2005 - Elsevier
Cyclosporine A (CsA) is the most widely used immunosuppressive drug for preventing graft
rejection and autoimmune disease. However, the therapeutic treatment induces several side …

Pharmacological agents under investigation in the treatment of coronavirus disease 2019 and the importance of melatonin

H Parlakpinar, S Polat, HA Acet - Fundamental & clinical …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a life‐threatening infectious respiratory
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

The Role of Melatonin on Behavioral Changes and Concomitant Oxidative Stress in icvAβ1-42 Rat Model with Pinealectomy

R Tzoneva, I Georgieva, N Ivanova, V Uzunova… - International Journal of …, 2021 - mdpi.com
One of the pathological hallmarks of Alzheimer's disease (AD) associated with its
progression that contributes to β-amyloid (Aβ) generation is oxidative stress (OS). Clinical …

Melatonin loaded PLGA nanoparticles effectively ameliorate the in vitro maturation of deteriorated oocytes and the cryoprotective abilities during vitrification process

S Lee, HJ Kim, HB Cho, HR Kim, S Lee, JI Park… - Biomaterials …, 2023 - pubs.rsc.org
Almost all cells can be exposed to stress, but oocytes, which are female germ cells, are
particularly vulnerable to damage. In this study, melatonin, a well-known antioxidant, was …

Diplomats' mystery illness and pulsed radiofrequency/microwave radiation

BA Golomb - Neural computation, 2018 - direct.mit.edu
Importance: A mystery illness striking US and Canadian diplomats to Cuba (and now
China)“has confounded the FBI, the State Department and US intelligence …