Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography

ES Olson, W Dong, BE Applegate, KK Charaziak… - Hearing Research, 2024 - Elsevier
Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a
vibrometer for hearing research. The application of OCT in this field, particularly for studying …

Cochlear amplification in the short-wave region by outer hair cells changing organ-of-Corti area to amplify the fluid traveling wave

JJ Guinan Jr - Hearing Research, 2022 - Elsevier
Many details of the operation of the mammalian cochlea are known, but how they all work
together to produce cochlear amplification is not understood. Outer-hair-cell (OHC) motility …

The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea

W He, G Burwood, EV Porsov, A Fridberger… - Scientific Reports, 2022 - nature.com
The prevailing theory of cochlear function states that outer hair cells amplify sound-induced
vibration to improve hearing sensitivity and frequency specificity. Recent micromechanical …

Organ of Corti vibrations are dominated by longitudinal motion in vivo

SWF Meenderink, W Dong - Communications Biology, 2022 - nature.com
Recent observations of sound-evoked vibrations of the cochlea's sensory organ of Corti
(ooC) using optical coherence tomography (OCT) have revealed unanticipated and complex …

Corti fluid is a medium for outer hair cell force transmission

M Shokrian, WC Lin, A Macić, JH Nam - Journal of Neuroscience, 2025 - jneurosci.org
The mammalian cochlea amplifies sounds selectively to improve frequency resolution.
However, vibrations around the outer hair cells (OHCs) are amplified nonselectively. The …

On the tonotopy of the low-frequency region of the cochlea

A Recio-Spinoso, W Dong, JS Oghalai - Journal of Neuroscience, 2023 - Soc Neuroscience
It is generally assumed that frequency selectivity varies along the cochlea. For example, at
the base of the cochlea, which is a region sensitive to high-frequency sounds, the best …

Regional differences in cochlear nonlinearity across the basal organ of Corti of gerbil: Regional differences in cochlear nonlinearity

CE Strimbu, LA Chiriboga, BL Frost, ES Olson - Hearing Research, 2024 - Elsevier
Auditory sensation is based in nanoscale vibration of the sensory tissue of the cochlea, the
organ of Corti complex (OCC). Motion within the OCC is now observable due to optical …

The spatial buildup of nonlinear compression in the cochlea

K Kondylidis, A Vavakou… - Frontiers in Cellular …, 2025 - search.proquest.com
In the mammalian cochlea, the transduction from vibrations to inner hair cell receptor
currents is preceded by a stage of mechanical pre-processing that involves a rapid, strongly …

Assessment of middle ear structure and function with optical coherence tomography

SWF Meenderink, M Warn, LM Anchondo… - Acta Oto …, 2023 - Taylor & Francis
Background Current clinical tests for middle ear (ME) injuries and related conductive
hearing loss (CHL) are lengthy and costly, lacking the ability to noninvasively evaluate both …

Imaging the Ear Anatomy and Function Using Optical Coherence Tomography Vibrometry

W Dong, SWF Meenderink - Seminars in Hearing, 2024 - thieme-connect.com
Optical coherence tomography (OCT) is a novel technology for performing real-time high-
speed and high-resolution cross-sectional imaging on the micro-scale in situ. It is analogous …