Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Denisovans, a group of now extinct humans who lived in Eastern Eurasia in the Middle and
Late Pleistocene, were first identified from DNA sequences just over a decade ago. Only ten …

The identification of a new hominin group in the Altai mountains called Denisovans was one
of the most exciting discoveries in human evolution in the last decade. Unlike Neanderthal …

Abstract Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a proteolytic enzyme involved
in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that …

The increasing availability of ancient DNA (aDNA) from human groups across space and
time has yielded deep insights into the movements of our species. However, given the …

The 3D structure of the genome is an important mediator of gene expression. As phenotypic
divergence is largely driven by gene regulatory variation, comparing genome 3D contacts …

Single-nucleotide polymorphisms (SNPs) near the ERAP2 gene are associated with various
autoimmune conditions, as well as protection against lethal infections. Due to high linkage …

When the ancestors of modern Eurasians migrated out of Africa and interbred with Eurasian
archaic hominins, namely, Neanderthals and Denisovans, DNA of archaic ancestry …

Phenotypic divergence between closely related species, including bonobos and
chimpanzees (genus Pan), is largely driven by variation in gene regulation. The 3D structure …

Results Here we traced the evolution of chronotype based on genomes from archaic
hominin and present-day humans. First, we inferred differences in circadian gene …