Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Purpose: The threat of a radiological/nuclear event is a critical concern for all government
agencies involved in national security and public health preparedness. Countermeasures …

Radiation‐induced lung injury (RILI) is a potentially fatal and dose-limiting complication of
thoracic cancer radiotherapy. However, effective therapeutic agents for this condition are …

The risk of internal and external exposure to ionizing radiation (IR) has increased alongside
the development and implementation of nuclear technology. Therefore, serious security …

Abstract Models of thoracic irradiation have been developed as clinicians and scientists
have attempted to decipher the events that led up to the pulmonary toxicity seen in human …

Purpose Terrorist use of nuclear weapons and radiation accidents put the human population
at risk for exposure to life-threatening levels of radiation. Victims of lethal radiation exposure …

Pneumonitis and fibrosis are potentially lethal, delayed effects of acute radiation exposure.
In this study, male rhesus macaques received whole-thorax lung irradiation (WTLI) with a …

AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic
specifically designed to neutralize reactive oxygen and nitrogen species. Research has …

Purpose: Radiation-induced lung injuries (RILI), namely radiation pneumonitis and/or
fibrosis, are dose-limiting outcomes following treatment for thoracic cancers. As part of a …

Research and development of medical countermeasures (MCMs) for radiation-induced lung
injury relies on the availability of animal models with well-characterized pathophysiology …