Despite daily fasting and feeding, plasma glucose levels are normally maintained within a
narrow range owing to the hormones insulin and glucagon. Insulin increases glucose …

Highlights•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …

Numerous endocytic accessory proteins (EAPs) mediate assembly and maturation of
clathrin-coated pits (CCPs) into cargo-containing vesicles. Analysis of EAP function through …

Zaire ebolavirus (ZEBOV), a highly pathogenic zoonotic virus, poses serious public health,
ecological and potential bioterrorism threats. Currently no specific therapy or vaccine is …

Endocytosis includes a number of processes by which cells internalize segments of their
plasma membrane, enclosing a wide variety of material from outside the cell. Endocytosis …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

In eukaryotic cells, protein sorting is a highly regulated mechanism important for many
physiological events. After synthesis in the endoplasmic reticulum and trafficking to the Golgi …

Dynamin is an atypical GTPase that catalyses membrane fission during clathrin-mediated
endocytosis. The mechanisms of dynamin's basal and assembly-stimulated GTP hydrolysis …

Dynamin, best studied for its role in clathrin-mediated endocytosis, is the prototypical
member of a family of multidomain GTPases involved in fission and remodeling of multiple …

The large GTPase dynamin assembles into higher order structures that are thought to
promote endocytosis. Dynamin also regulates the actin cytoskeleton through an unknown …