Ion channels are integral membrane proteins whose gating has been increasingly shown to
depend on the presence of the low-abundance membrane phospholipid …

Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD)
structural domains. During voltage-dependent gating, conformational changes in the two …

Pressor effects of the vasoconstrictor hormone arginine vasopressin (AVP), observed when
systemic AVP concentrations are less than 100 pM, are important for the physiological …

Voltage-gated ion channels are crucial for both neuronal and cardiac excitability. Decades
of research have begun to unravel the intriguing machinery behind voltage sensitivity …

Voltage‐evoked signals play critical roles in neural activities, muscle contraction and
exocytosis. Ciona voltage‐sensor containing phosphatase (Ci‐VSP) consists of the …

Little is known about which ion channels determine the resting electrical properties of
presynaptic membranes. In recordings made from the rat calyx of Held, a giant mammalian …

The Kv7 family (Kv7. 1–7.5) of voltage-activated potassium channels contributes to the
maintenance of resting membrane potential in excitable cells. Previously, we provided …

Acetylcholine is a neuromodulator critical for learning and memory. The cholinesterase
inhibitor donepezil increases brain acetylcholine levels and improves Alzheimer's disease …

Abstract KCNQ family K+ channels (KCNQ1-5) in the heart, nerve, epithelium and ear
require phosphatidylinositol 4, 5-bisphosphate (PIP2) for voltage dependent activation …

Phosphatidylinositol 4, 5-bisphosphate (PIP 2) in the plasma membrane regulates the
function of many ion channels, including M-type (potassium voltage-gated channel …