[HTML][HTML] Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases

AL Onugwu, CS Nwagwu, OS Onugwu… - Journal of Controlled …, 2023 - Elsevier
Diseases affecting the anterior segment of the eye are the primary causes of vision
impairment and blindness globally. Drug administration through the topical ocular route is …

Cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems

B Gupta, V Mishra, S Gharat, M Momin, A Omri - Pharmaceuticals, 2021 - mdpi.com
One of the major impediments to drug development is low aqueous solubility and thus poor
bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the …

Chitosan and its derivatives for ocular delivery formulations: Recent advances and developments

A Zamboulis, S Nanaki, G Michailidou, I Koumentakou… - Polymers, 2020 - mdpi.com
Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

Therapeutic nanoemulsions in ophthalmic drug administration: Concept in formulations and characterization techniques for ocular drug delivery

M Singh, S Bharadwaj, KE Lee, SG Kang - Journal of Controlled Release, 2020 - Elsevier
The eye is the specialized part of the body and is comprised of numerous physiological
ocular barriers that limit the drug absorption at the action site. Regardless of various efforts …

Hydrogels-based ophthalmic drug delivery systems for treatment of ocular diseases

G Fang, X Yang, Q Wang, A Zhang, B Tang - Materials Science and …, 2021 - Elsevier
An increasing number of people worldwide are affected by eye diseases, eventually leading
to visual impairment or complete blindness. Conventional treatment involves the use of eye …

[HTML][HTML] Recent developments of nanostructures for the ocular delivery of natural compounds

MS Razavi, P Ebrahimnejad, Y Fatahi… - Frontiers in …, 2022 - frontiersin.org
Ocular disorders comprising various diseases of the anterior and posterior segments are
considered as the main reasons for blindness. Natural products have been identified as …

Hyaluronic-coated albumin nanoparticles for the non-invasive delivery of apatinib in diabetic retinopathy

SES Radwan, A El-Kamel, EI Zaki… - International Journal …, 2021 - Taylor & Francis
Purpose Apatinib (Apa) is a novel anti-vascular endothelial growth factor with the potential to
treat diabetic retinopathy (DR); a serious condition leading to visual impairment and …

Challenges and strategies for ocular posterior diseases therapy via non-invasive advanced drug delivery

Q Qi, Y Wei, X Zhang, J Guan, S Mao - Journal of Controlled Release, 2023 - Elsevier
Posterior segment diseases, such as age-related macular degeneration (AMD) and diabetic
retinopathy (DR) are vital factor that seriously threatens human vision health and quality of …

[HTML][HTML] Nanoemulsions as ophthalmic drug delivery systems

RK Dhahir, AM Al-Nima, ALB Fadia - Turkish Journal of …, 2021 - ncbi.nlm.nih.gov
Nanoemulsions are liquid-in-liquid dispersion with a droplet size of about 100 nm. They
have a transparent appearance, high rate of bioavailability, and increased shelf life …

Trends in formulation approaches for sustained drug delivery to the posterior segment of the eye

A Biswas, AD Choudhury, AC Bisen, S Agrawal… - AAPS …, 2023 - Springer
The eye, an intricate organ comprising physical and physiological barriers, poses a
significant challenge for ophthalmic physicians seeking to treat serious ocular diseases …