From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

T Efferth - Seminars in cancer biology, 2017 - Elsevier
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis

L Shu, KL Cheung, TO Khor, C Chen… - Cancer and Metastasis …, 2010 - Springer
Carcinogenesis is a multi-step process which could be prevented by phytochemicals.
Phytochemicals from dietary plants and other plant sources such as herbs are becoming …

[PDF][PDF] Anti-inflammatory, antioxidant and antimicrobial effects of artemisinin extracts from Artemisia annua L.

WS Kim, WJ Choi, S Lee, WJ Kim… - The Korean journal …, 2015 - synapse.koreamed.org
There has been an increase is the reevaluation of traditional medicinal plants worldwide,
with extensive research on various plant species and their therapeutic properties being …

Toxicity of the antimalarial artemisinin and its dervatives

T Efferth, B Kaina - Critical reviews in toxicology, 2010 - Taylor & Francis
As long as no effective malaria vaccine is available, chemotherapy belongs to the most
important weapons fighting malaria. One of the most promising new drug developments is …

Traditionally used Thai medicinal plants: in vitro anti-inflammatory, anticancer and antioxidant activities

N Siriwatanametanon, BL Fiebich, T Efferth… - Journal of …, 2010 - Elsevier
AIMS OF THE STUDY: In order to assess traditional Thai claims about the therapeutic
potential of medicinal plants and to select plants for future phytochemical research, nine …

Probing the biology of natural products: molecular editing by diverted total synthesis

AM Szpilman, EM Carreira - Angewandte Chemie International …, 2010 - Wiley Online Library
The systematic modification of natural products through diverted total synthesis is a powerful
concept for the systematic modification of natural products with the aim of studying …

Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma

S Sertel, T Eichhorn, PK Plinkert, T Efferth - Anticancer research, 2011 - ar.iiarjournals.org
Background: Oral cavity squamous cell carcinoma (OCSCC) accounts for 2% to 3% of all
malignancies and has a high mortality rate. The majority of anticancer drugs are of natural …

Artemisinin and its derivatives in cancer therapy: status of progress, mechanism of action, and future perspectives

A Bhaw-Luximon, D Jhurry - Cancer chemotherapy and pharmacology, 2017 - Springer
Since the late 1990s, there has been rapid multiplication of data on the anti-cancer
properties of artemisinins. This article reviews the status of progress of artemisinin and its …

Anti-Inflammatory Activity of Methyl Salicylate Glycosides Isolated from Gaultheria yunnanensis (Franch.) Rehder

D Zhang, R Liu, L Sun, C Huang, C Wang, DM Zhang… - Molecules, 2011 - mdpi.com
Gaultheria yunnanensis (Franch.) Rehder is a kind of traditional Chinese herbal medicine
used for the treatments of rheumatoid arthritis, swelling and pain. Two methyl salicylate …

Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells

M Youns, T Efferth, J Reichling, K Fellenberg… - Biochemical …, 2009 - Elsevier
Pancreatic cancer is one of the most aggressive human malignancies, with an extremely
poor prognosis. The paucity of curative therapies has translated into an overall 5-year …