The intrinsic pathogenetic mechanisms of tendinopathies are largely unknown and whether
inflammation or degeneration has the prominent role is still a matter of debate. Assuming …

Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As
the human population ages and the life expectancy increases, tendon injuries will become …

Current stem cell–based strategies for tissue regeneration involve ex vivo manipulation of
these cells to confer features of the desired progenitor population. Recently, the concept that …

The last decade has seen significant developments in cell therapies, based on permanently
differentiated, reprogrammed or engineered stem cells, for tendon injuries and degenerative …

Tendons are dense connective tissues with a hierarchical polarized structure that respond to
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …

Mesenchymal stem cell therapy is a novel regenerative approach for treating tendinopathy.
Here, we evaluated the safety and efficacy of allogeneic adipose-derived mesenchymal …

Introduction Tendon injuries give rise to significant morbidity. In the last few decades,
several techniques have been increasingly used to optimize tendon healing. Sources of …

We developed a (three-dimensional) 3D scaffold, we named HY-FIB, incorporating a force-
transmission band of braided hyaluronate embedded in a cell localizing fibrin hydrogel and …

Substrates with mechanical property gradients and various extracellular matrix ligand
loadings were evaluated for their ability to direct bone marrow stromal cell differentiation …

Tendon injuries and defects present a substantial burden to global healthcare economies.
There are no synthetic/biosynthesised implants available which can restore full function or …