The presence of a mucus layer that covers the surface of a variety of organs has been
capitalized to develop mucoadhesive dosage forms that remain in the administration site for …

Developability molecule assessment is a key interfacial capability across the
biopharmaceutical industry, screening and staging molecules discovered by medicinal …

Monoclonal antibodies play an increasingly important role for the development of new drugs
across multiple therapy areas. The term 'developability'encompasses the feasibility of …

This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …

Antibodies developed for research and clinical applications may exhibit suboptimal stability,
expressibility, or affinity. Existing optimization strategies focus on surface mutations …

Poor aqueous solubility of drugs is still a foremost challenge in pharmaceutical product
development. The use of lipids in designing formulations provides an opportunity to …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

Cocrystals are crystalline single phase materials composed of two or more different
molecular and/or ionic compounds generally in a stoichiometric ratio which are neither …

Current treatments for intestinal diseases including inflammatory bowel diseases, irritable
bowel syndrome, and colonic bacterial infections are typically small molecule oral dosage …