Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

Astrocytes play important roles in numerous central nervous system disorders including
autoimmune inflammatory, hypoxic, and degenerative diseases such as Multiple Sclerosis …

While lymphocytopenia is a common characteristic of coronavirus disease 2019 (COVID-
19), the mechanisms responsible for this lymphocyte depletion are unclear. Here, we …

A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

Despite dramatic improvements in the management of traumatic brain injury (TBI), to date
there is no effective treatment available to patients, and morbidity and mortality remain high …

The success of cancer immunotherapy in solid tumors depends on a sufficient distribution of
effector T cells into malignant lesions. However, immune-cold tumors utilize many T-cell …

Interactions between the immune system and malignant cells play an important role in
tumorigenesis. Failure of the immune system to detect and reject transformed cells may lead …

Publisher Summary This chapter highlights the controversies concerning the role of brain
inflammation elicited after brain trauma. In clinical practice, classification of primary brain …

Astrocytes, the most abundant glial cell types in the brain, provide metabolic and trophic
support to neurons and modulate synaptic activity. Accordingly, impairment in these …

The physiological function of interleukin-6 (IL-6) within the central nervous system (CNS) is
complex; IL-6 exerts neurotrophic and neuroprotective effects, and yet can also function as a …