The use of Drosophila in neurodegenerative disease research has contributed to the
identification of modifier genes for the pathology. The basis for neurodegenerative disease …

SRSF1 (also known as ASF/SF2) is a non-small nuclear ribonucleoprotein (non-snRNP) that
belongs to the arginine/serine (R/S) domain family. It recognizes and binds to mRNA …

About two-thirds of the vital genes in the Drosophila genome are involved in eye
development, making the fly eye an excellent genetic system to study cellular function and …

Environmental insults such as oxidative stress can damage cell membranes. Lysosomes are
particularly sensitive to membrane permeabilization since their function depends on …

Purpose Alzheimer's disease (AD) is the most common form of tauopathy that usually
occursduring aging and unfolded protein response (UPR), oxidative stress and autophagy …

Under normal physiological conditions, the mammalian brain contains very little glycogen,
most of which is stored in astrocytes. However, the aging brain and the subareas of the brain …

Parkinson's disease (PD) is an age‐associated neurodegenerative condition in which some
genetic variants are known to increase disease susceptibility on interaction with …

Alzheimer's disease (AD) is one of the most common forms of neurodegenerative diseases.
Aggregation of Aβ42 and hyperphosphorylated tau are two major hallmarks of AD. Whether …

Alzheimer's disease is characterized by 2 pathological proteins, amyloid beta 42 and tau.
The majority of Alzheimer's disease cases in the population are sporadic and late-onset …

Alzheimer's disease (AD) is a progressive neurodegenerative condition and the primary
form of dementia among elderly people. The amyloidogenic hypothesis is the main theory …