Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

The dynamin GTPase is known to bundle actin filaments, but the underlying molecular
mechanism and physiological relevance remain unclear. Our genetic analyses revealed a …

Podosomes are dynamic adhesion structures formed constitutively by macrophages,
dendritic cells and osteoclasts and transiently in a wide variety of cells, such as endothelial …

Podosomes are ubiquitous cellular structures important to diverse processes including cell
invasion, migration, bone resorption, and immune surveillance. Structurally, podosomes …

Macrophages play a critical role in regulating immune reactions induced by implanted
biomaterials. They are highly plastic and in response to diverse stimuli in the …

Podosomes are highly dynamic actin-rich structures in a variety of cell types, especially
monocytic cells. They fulfill multiple functions such as adhesion, mechanosensing, or …

Podosomes, an important actin-based adhesive architecture, play critical roles in cell
migration and matrix invasiveness. Here, we elucidate the ultrastructural organization and …

Alzheimer's disease (AD) is a neurodegenerative disease mainly associated with aging,
oxidative stress and genetic mutations. There are two pathological proteins involved in AD; …

Podosomes are integrin-mediated cell adhesion units involved in many cellular and
physiological processes. Integrins likely transmit tensions critical for podosome functions …