The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Vascular disease and heart failure impart an enormous burden in terms of global morbidity
and mortality. Although there are many different causes of cardiac and vascular disease …

Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO·
synthase (eNOS) is responsible for most of the vascular NO· produced. A functional eNOS …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Cardiovascular disease (CVD) is a universal problem in modern society. Atherosclerosis is
the leading cause of CVD resulting in high rate of mortality in the population. Nutrition …

Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone,
inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the …

Systemic arterial hypertension is a highly prevalent cardiovascular risk factor that causes
significant morbidity and mortality, and is becoming an increasingly common health problem …

Healthy vascular function is primarily regulated by several factors including EDRF
(endothelium-dependent relaxing factor), EDCF (endothelium-dependent contracting factor) …

The mechanism of superoxide generation by endothelial nitric oxide synthase (eNOS) was
investigated by the electron spin resonance spin-trapping technique using 5 …