The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

Local intracellular Ca2+ transients, termed Ca2+ sparks, are caused by the coordinated
opening of a cluster of ryanodine-sensitive Ca2+ release channels in the sarcoplasmic …

BK large conductance voltage-and calcium-activated potassium channels respond to
elevations in intracellular calcium and membrane potential depolarization, braking …

The sarcoplasmic reticulum (SR) of smooth muscles presents many intriguing facets and
questions concerning its roles, especially as these change with development, disease, and …

▪ Abstract The main contributors to increases in [Ca2+] i and tension are the entry of Ca2+
through voltage-dependent channels opened by depolarization or during action potential …

Smooth muscle (SM) is essential to all aspects of human physiology and, therefore, key to
the maintenance of life. Ion channels expressed within SM cells regulate the membrane …

Intracellular calcium ions are involved in the regulation of nearly every aspect of cell
function. In smooth muscle, Ca2+ can be delivered to Ca2+-sensitive effector molecules …

Calcium-induced calcium release (CICR) has been observed in cardiac myocytes as
elementary calcium release events (calcium sparks) associated with the opening of L-type …

This study examines the roles of voltage-dependent Ca2+ channels (VDCC), ryanodine
receptors (RyRs), large-conductance Ca2+-activated K+ (BK) channels, and small …

The lower urinary tract is a muscular system composed of the urinary bladder and the
outflow tract. During filling with urine the bladder is relaxed and the outflow tract offers a high …