Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER
protein homeostasis is essential for the coordination of its diverse functions and depends on …

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite
for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular …

Isoprenoid biosynthesis is essential for all living organisms, and isoprenoids are also of
industrial and agricultural interest. All isoprenoids are derived from prenyl diphosphate …

Recently, targeting metabolic reprogramming has emerged as a potential therapeutic
approach for fighting cancer. Sterol regulatory element binding protein-2 (SREBP-2), a basic …

Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …

Cholesterol is an essential component of animal cell membranes, and its concentration is
tightly controlled by a feedback system that operates at transcriptional and …

Proprotein convertase subtilisin kexin 9 (Pcsk9) is a subtilisin serine protease with a putative
role in cholesterol metabolism. Pcsk9 expression is down-regulated by dietary cholesterol …

Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol
biosynthesis, and have been clinically used to treat cardiovascular disease. However, a …