cis-Regulatory elements encode the genomic blueprints that ensure the proper
spatiotemporal patterning of gene expression necessary for appropriate development and …

The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

Gene expression in bacteria relies on promoter recognition by the DNA-dependent RNA
polymerase and subsequent transcription initiation. Bacterial cells are able to tune their …

Integrative structure determination is a powerful approach to modeling the structures of
biological systems based on data produced by multiple experimental and theoretical …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Over the last decade, a rich variety of massively parallel assays have revolutionized our
understanding of how biological sequences encode quantitative molecular phenotypes …

Transcription activation is established through extensive protein–protein and protein–DNA
interactions that allow an activator to engage and remodel RNA polymerase. SoxS, a global …

Transcription factors play an indispensable role in maintaining cellular viability and finely
regulating complex internal metabolic networks. These crucial bioactive functions rely on …

Studies of transcriptional initiation in different bacterial clades reveal diverse molecular
mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are …

Transcription is the first and most heavily regulated step in gene expression. Sigma (σ)
factors are general transcription factors that reversibly bind RNA polymerase (RNAP) and …