Multifaceted functions of RPS27a: An unconventional ribosomal protein
J Luo, H Zhao, L Chen, M Liu - Journal of Cellular Physiology, 2023 - Wiley Online Library
The ribosomal protein S27a (RPS27a) is cleaved from the fusion protein ubiquitin–RPS27a
(Ub–RPS27a). Generally, Ub and RPS27a are coexpressed as a fusion protein but function …
(Ub–RPS27a). Generally, Ub and RPS27a are coexpressed as a fusion protein but function …
Identification of diagnostic genes for both Alzheimer's disease and Metabolic syndrome by the machine learning algorithm
J Li, Y Zhang, T Lu, R Liang, Z Wu, M Liu, L Qin… - Frontiers in …, 2022 - frontiersin.org
Background Alzheimer's disease is the most common neurodegenerative disease
worldwide. Metabolic syndrome is the most common metabolic and endocrine disease in the …
worldwide. Metabolic syndrome is the most common metabolic and endocrine disease in the …
Disease-and headache-specific microRNA signatures and their predicted mRNA targets in peripheral blood mononuclear cells in migraineurs: role of inflammatory …
Background Migraine is a primary headache with genetic susceptibility, but the
pathophysiological mechanisms are poorly understood, and it remains an unmet medical …
pathophysiological mechanisms are poorly understood, and it remains an unmet medical …
scIBD: a self-supervised iterative-optimizing model for boosting the detection of heterotypic doublets in single-cell chromatin accessibility data
Application of the widely used droplet-based microfluidic technologies in single-cell
sequencing often yields doublets, introducing bias to downstream analyses. Especially …
sequencing often yields doublets, introducing bias to downstream analyses. Especially …
Cancer-related cognitive impairment is associated with perturbations in inflammatory pathways
Cancer-related cognitive impairment (CRCI) is a significant problem for patients receiving
chemotherapy. While a growing amount of pre-clinical and clinical evidence suggests that …
chemotherapy. While a growing amount of pre-clinical and clinical evidence suggests that …
Identification of differential genes of DNA methylation associated with Alzheimer's disease based on integrated bioinformatics and its diagnostic significance
F Chen, N Wang, X He - Frontiers in Aging Neuroscience, 2022 - frontiersin.org
Background Alzheimer's disease (AD) is a common neurodegenerative disease. The
pathogenesis is complex and has not been clearly elucidated, and there is no effective …
pathogenesis is complex and has not been clearly elucidated, and there is no effective …
RT-DOb, a switch gene for the gene pair {Csf1r, Milr1}, can influence the onset of Alzheimer's disease by regulating communication between mast cell and microglia
In biology, homeostasis is a central cellular phenomenon that plays a crucial role in survival.
The central nervous system (CNS) is controlled by exquisitely sensitive homeostatic …
The central nervous system (CNS) is controlled by exquisitely sensitive homeostatic …
Blood-based transcriptomic biomarkers are predictive of neurodegeneration rather than Alzheimer's disease
Alzheimer's disease (AD) is a growing global health crisis affecting millions and incurring
substantial economic costs. However, clinical diagnosis remains challenging, with …
substantial economic costs. However, clinical diagnosis remains challenging, with …
Modulating the RPS27A/PSMD12/NF-κB pathway to control immune response in mouse brain ischemia-reperfusion injury
X Li, M Qiao, Y Zhou, Y Peng, G Wen, C Xie… - Molecular Medicine, 2024 - Springer
Background Investigating immune cell infiltration in the brain post-ischemia-reperfusion (I/R)
injury is crucial for understanding and managing the resultant inflammatory responses. This …
injury is crucial for understanding and managing the resultant inflammatory responses. This …
S100a9 might act as a modulator of the Toll-like receptor 4 transduction pathway in chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis with nasal polyp (CRSwNP) is a highly prevalent disorder
characterized by persistent nasal and sinus mucosa inflammation. Despite significant …
characterized by persistent nasal and sinus mucosa inflammation. Despite significant …