Cellular metabolism hijacked by viruses for immunoevasion: potential antiviral targets
J Li, Y Wang, H Deng, S Li, HJ Qiu - Frontiers in Immunology, 2023 - frontiersin.org
Cellular metabolism plays a central role in the regulation of both innate and adaptive
immunity. Immune cells utilize metabolic pathways to modulate the cellular differentiation or …
immunity. Immune cells utilize metabolic pathways to modulate the cellular differentiation or …
Exploring Druggable Binding Sites on the Class A GPCRs Using the Residue Interaction Network and Site Identification by Ligand Competitive Saturation
G protein-coupled receptors (GPCRs) play a central role in cellular signaling and are linked
to many diseases. Accordingly, computational methods to explore potential allosteric sites …
to many diseases. Accordingly, computational methods to explore potential allosteric sites …
Identification of defactinib derivatives targeting focal adhesion kinase using ensemble docking, molecular dynamics simulations and binding free energy calculations
C Guo, Q Li, J Xiao, F Ma, X Xia… - Journal of Biomolecular …, 2023 - Taylor & Francis
Focal adhesion kinase (FAK) belongs to the nonreceptor tyrosine kinases, which selectively
phosphorylate tyrosine residues on substrate proteins. FAK is associated with bladder …
phosphorylate tyrosine residues on substrate proteins. FAK is associated with bladder …
A computational workflow to determine drug candidates alternative to aminoglycosides targeting the decoding center of E. coli ribosome
The global antibiotic resistance problem necessitates fast and effective approaches to
finding novel inhibitors to treat bacterial infections. In this study, we propose a computational …
finding novel inhibitors to treat bacterial infections. In this study, we propose a computational …