Identification of B‐cell epitopes is a fundamental step for development of epitope‐based
vaccines, therapeutic antibodies, and diagnostic tools. Epitope‐based antibodies are …

Exploitation of recombinant DNA and sequencing technologies has led to a new concept in
vaccination in which isolated epitopes, capable of stimulating a specific immune response …

Background One of the major challenges in the field of vaccine design is to predict
conformational B-cell epitopes in an antigen. In the past, several methods have been …

The structures of protein antigen–antibody (Ag–Ab) interfaces contain information about how
Ab recognize Ag as well as how Ag are folded to present surfaces for Ag recognition. As …

The conventional approach for designing vaccine against a particular disease involves
stimulation of the immune system using the whole pathogen responsible for the disease. In …

Identification of epitopes which invoke strong humoral responses is an essential issue in the
field of immunology. Localizing epitopes by experimental methods is expensive in terms of …

As epitope mimics, mimotopes have been widely utilized in the study of epitope prediction
and the development of new diagnostics, therapeutics, and vaccines. Screening the random …

Mimotopes are peptides with affinities to given targets. They are readily obtained through
biopanning against combinatorial peptide libraries constructed by phage display and other …

Most protein therapeutics have the potential to induce undesirable immune responses in
patients. Many patients develop anti-therapeutic antibodies, which can affect the safety and …

A large volume of data relevant to immunology research has accumulated due to
sequencing of genomes of the human and other model organisms. At the same time, huge …