Advances in oral drug delivery for regional targeting in the gastrointestinal tract-influence of physiological, pathophysiological and pharmaceutical factors

S Hua - Frontiers in pharmacology, 2020 - frontiersin.org
The oral route is by far the most common route of drug administration in the gastrointestinal
tract and can be used for both systemic drug delivery and for treating local gastrointestinal …

Advances in oral drug delivery systems: Challenges and opportunities

J Lou, H Duan, Q Qin, Z Teng, F Gan, X Zhou, X Zhou - Pharmaceutics, 2023 - mdpi.com
The oral route is the most preferred route for systemic and local drug delivery. However, the
oral drug delivery system faces the harsh physiological and physicochemical environment of …

[HTML][HTML] Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products

K Zöller, D To, A Bernkop-Schnürch - Biomaterials, 2024 - Elsevier
Functional hydrogels are used for numerous biomedical applications such as tissue
engineering, wound dressings, lubricants, contact lenses and advanced drug delivery …

Design and fabrication of drug‐delivery systems toward adjustable release profiles for personalized treatment

A Geraili, M Xing, K Mequanint - View, 2021 - Wiley Online Library
Advanced polymeric controlled delivery systems are designed to effectively treat chronic
diseases by adjusting the temporal profile of drug release. Most conventional controlled …

Gastroretentive technologies in tandem with controlled-release strategies: A potent answer to oral drug bioavailability and patient compliance implications

NN Vrettos, CJ Roberts, Z Zhu - Pharmaceutics, 2021 - mdpi.com
There have been many efforts to improve oral drug bioavailability and therapeutic efficacy
and patient compliance. A variety of controlled-release oral delivery systems have been …

Utilizing 4D printing to design smart gastroretentive, esophageal, and intravesical drug delivery systems

DB Mahmoud… - Advanced Healthcare …, 2023 - Wiley Online Library
The breakthrough of 3D printing in biomedical research has paved the way for the next
evolutionary step referred to as four dimensional (4D) printing. This new concept utilizes the …

Enhancing Oral Absorption of Orlistat through Gastroretentive Mucoadhesive Pellets: Formulation and Evaluation

UK Thummala, PS Vallabhareddy, PNK Sarella - Journal of Clinical and …, 2023 - jcpr.in
Aim: The aim of this study was to develop gastroretentive mucoadhesive pellets of Orlistat to
improve its oral bioavailability and enhance its absorption. Methods: Orlistat pellets were …

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

C Chen, A Beloqui, Y Xu - Advanced drug delivery reviews, 2023 - Elsevier
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …

[HTML][HTML] Gastric fluid-induced double network hydrogel with high swelling ratio and long-term mechanical stability

X Jin, C Wei, C Wu, W Zhang - Composites Part B: Engineering, 2022 - Elsevier
Hydrogels have been widely investigated as gastric retention systems for drug delivery and
bariatric intervention due to their good biocompatibility, degradability, and similarity with …

Gastro-retentive drug delivery systems: A recent update on clinical pertinence and drug delivery

S Das, S Kaur, VK Rai - Drug Delivery and Translational Research, 2021 - Springer
Gastro-retentive drug delivery systems are some of the best technologies delivered through
oral route. These mainly came into picture for their effective local action in the GI region …