Recent advances in prostate cancer treatment and drug discovery

E Nevedomskaya, SJ Baumgart… - International journal of …, 2018 - mdpi.com
Novel drugs, drug sequences and combinations have improved the outcome of prostate
cancer in recent years. The latest approvals include abiraterone acetate, enzalutamide and …

The future of PSMA-targeted radionuclide therapy: an overview of recent preclinical research

EAM Ruigrok, WM van Weerden, J Nonnekens… - Pharmaceutics, 2019 - mdpi.com
Prostate specific membrane antigen (PSMA) has become a major focus point in the research
and development of prostate cancer (PCa) imaging and therapeutic strategies using …

Nuclear medicine and molecular imaging advances in the 21st century

SC Vaz, F Oliveira, K Herrmann… - The British journal of …, 2020 - academic.oup.com
Currently, Nuclear Medicine has a clearly defined role in clinical practice due to its
usefulness in many medical disciplines. It provides relevant diagnostic and therapeutic …

In vitro dose effect relationships of actinium-225-and lutetium-177-labeled PSMA-I&T

EAM Ruigrok, G Tamborino, E de Blois… - European Journal of …, 2022 - Springer
Purpose Targeting the prostate-specific membrane antigen (PSMA) using lutetium-177-
labeled PSMA-specific tracers has become a very promising novel therapy option for …

PSMA: a game changer in the diagnosis and treatment of advanced prostate cancer

M Parsi, MH Desai, D Desai, S Singhal… - Medical Oncology, 2021 - Springer
Although management of advanced prostate cancer is evolving, a lot of work remains to be
done for patients who have exhausted all options. Molecular targeting of prostate specific …

The inflammatory macrophages repress the growth of bone metastatic human prostate cancer cells via TNF-α and IL-6 signaling: Involvement of cell signaling …

M Yamaguchi, K Hashimoto, M Jijiwa, T Murata - Cellular Signalling, 2023 - Elsevier
Macrophages in the cancer microenvironments may play a regulatory role in the progression
and metastasis of prostate cancer cells. However, the crosstalk between macrophages and …

Regucalcin Is a Potential Regulator in Human Cancer: Aiming to Expand into Cancer Therapy

M Yamaguchi - Cancers, 2023 - mdpi.com
Simple Summary Regucalcin plays a multifunctional role in the regulation of cell function
and expresses a repressive effect in the growth of normal cells. Of note, there is increasing …

Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after …

D Tarallo, J Martínez, A Leyva, A Mónaco, C Perroni… - Scientific Reports, 2024 - nature.com
Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated
secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing …

Commercial and business aspects of alpha radioligand therapeutics

E Ostuni, MRG Taylor - Frontiers in Medicine, 2023 - frontiersin.org
Radioligand therapy (RLT) is gaining traction as a safe and effective targeted approach for
the treatment of many cancer types, reflected by a substantial and growing commercial …

Cellular and genetic determinants of the sensitivity of cancer to α-particle irradiation

BD Yard, P Gopal, K Bannik, G Siemeister… - Cancer research, 2019 - AACR
Targeted α-particle–emitting radionuclides have great potential for the treatment of a broad
range of cancers at different stages of progression. A platform that accurately measures …