Exploiting quorum sensing to confuse bacterial pathogens

B LaSarre, MJ Federle - Microbiology and molecular biology …, 2013 - Am Soc Microbiol
Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that
is used to coordinate gene expression among local populations. Its use by bacterial …

Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways

WRJD Galloway, JT Hodgkinson, SD Bowden… - Chemical …, 2011 - ACS Publications
Numerous species of bacteria employ a mechanism of intercellular communication known
as quorum sensing. This signaling process allows the cells comprising a bacterial colony to …

Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing

C Fuqua, MR Parsek, EP Greenberg - Annual review of genetics, 2001 - annualreviews.org
▪ Abstract Quorum sensing is an example of community behavior prevalent among diverse
bacterial species. The term “quorum sensing” describes the ability of a microorganism to …

Natural products as inspiration for the development of bacterial antibiofilm agents

RJ Melander, AK Basak, C Melander - Natural product reports, 2020 - pubs.rsc.org
Natural products have historically been a rich source of diverse chemical matter with
numerous biological activities, and have played an important role in drug discovery in many …

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound

M Hentzer, K Riedel, TB Rasmussen… - …, 2002 - microbiologyresearch.org
Novel molecular tools have been constructed which allow for in situ detection of N-acyl
homoserine lactone (AHL)-mediated quorum sensing in Pseudomonas aeruginosa biofilms …

Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

M Hentzer, M Givskov - The Journal of clinical investigation, 2003 - Am Soc Clin Investig
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit
bacterial growth. A major concern with this approach is the frequently observed …

Microalgae as sources of pharmaceuticals and other biologically active compounds

MA Borowitzka - Journal of applied phycology, 1995 - Springer
In the last decade the screening of microalgae, especially the cyanobacteria (blue-green
algae), for antibiotics and pharmacologically active compounds has received ever …

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

M Givskov, R de Nys, M Manefield, L Gram… - Journal of …, 1996 - Am Soc Microbiol
Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication
among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites …

Quorum-Sensing Genes in Pseudomonas aeruginosa Biofilms: Their Role and Expression Patterns

TR De Kievit, R Gillis, S Marx, C Brown… - Applied and …, 2001 - Am Soc Microbiol
Acylated homoserine lactone molecules are used by a number of gram-negative bacteria to
regulate cell density-dependent gene expression by a mechanism known as quorum …

Microalgae as sources of high added‐value compounds—a brief review of recent work

AC Guedes, HM Amaro, FX Malcata - Biotechnology progress, 2011 - Wiley Online Library
Microalgae have found commercial applications as natural sources of valuable
macromolecules, including carotenoids, long‐chain polyunsaturated fatty acids, and …