Osteosarcoma, the most common malignant tumor of the bone, seriously influences people's
lives and increases their economic burden. Conventional chemotherapy drugs achieve …

Genetic studies have been instrumental in the field of orthopaedics for finding tools to
improve the standard management of fractures and delayed unions. The Wnt signaling …

Periodontitis is a chronic inflammatory disease caused by complex interactions between the
host immune system and pathogens that affect the integrity of periodontium. To prevent …

Loading hydrogels with bioactive agents is an important method for expanding the functional
application of hydrogels. However, how to improve the local administration and slow release …

Despite several decades of progress, bone-specific drug delivery is still a major challenge.
Current bone-acting drugs require high-dose systemic administration which decreases …

Stem cells are well-known for their great capacity for tissue regeneration. This provides a
promising source for cell-based therapies in treating various bone degenerative disorders …

Impaired fracture healing is a major clinical problem that can lead to patient disability,
prolonged hospitalization, and significant financial burden. Although the majority of fractures …

Seasonal influenza epidemics lead to 3–5 million severe infections and 290,000–650,000
annual global deaths. With deaths from the 1918 influenza pandemic estimated at> …

Bone defects of critical size after compound fractures, infections, or tumor resections are a
challenge in treatment. Particularly, this applies to bone defects in patients with impaired …

Despite widespread use of conventional diagnostic methods in orthopedic applications,
limitations still exist in detection and diagnosing many pathologies, especially at early …