Metabolic bone disease is a common complication of chronic kidney disease (CKD) and is
part of a broad spectrum of disorders of mineral metabolism that occur in this clinical setting …

Secondary hyperparathyroidism classically appears during the course of chronic renal
failure and sometimes after renal transplantation. Understanding the mechanisms by which …

The resistance of parathyroid cells to 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3) in uremic
hyperparathyroidism is thought to be caused, in part, by a 1, 25 (OH) 2D3 receptor (VDR) …

Pathogenesis of secondary hyperparathyroidism. Secondary hyperparathyroidism is a
universal complication in patients with chronic renal failure. Hyperplasia of the parathyroid …

The identification of the calcium-sensing receptor (CaSR) and the clarification of its role as
the major regulator of parathyroid gland function have important implications for …

In vivo in the rat 1, 25 (OH) 2D3 decreases and a low calcium increases PTH mRNA levels.
We now report the effect of 3 and 8 wk of changes in dietary vitamin D and calcium on PTH …

Our understanding of the mechanism responsible for secondary hyperparathyroidism
(HPTH) has advanced significantly since the “trade-off” hypothesis was formulated. It …

Renal osteodystrophy presents with a spectrum of histologic abnormalities. A new entity
characterized by a marked decrease in bone turnover without osteoid accumulation, that is …

Hypocalcemia based on serum tCa is a relatively common laboratory abnormality and was
observed in 13.5% of serum biochemical profiles of dogs in one clinical study. 111 Based on …

Eighty cats with chronic renal failure (CRF) were evaluated in a prospective study to
investigate the prevalence and aetiopathogenesis of renal secondary hyperparathyroidism …