Toxoplasmosis is one of the highly prevalent zoonotic diseases worldwide caused by the
parasite Toxoplasma gondii (T. gondii). The infection with T. gondii could pass unidentified …

The mechanistic (or mammalian) target of rapamycin (mTOR) is considered as a critical
regulatory enzyme involved in essential signaling pathways affecting cell growth, cell …

Abstract Objectives Calcium oxalate (CaOx) crystals can activate inflammatory cytokines by
triggering inflammasomes, which cause damage to the adhered epithelium, a dysfunctional …

Background Inflammation of RPE cells led to different kinds of eye diseases and affected the
normal function of the retina. Furthermore, higher levels of ROCK1 and ROCK2 induced …

Toxoplasma gondii is a ubiquitous obligate intracellular parasite that infects the nucleated
cells of warm-blooded animals. From within the parasitophorous vacuole in which they …

Invasion and metastasis represent the primary causes of therapeutic failure in patients
diagnosed with esophageal squamous cell carcinoma (ESCC). The lack of effective …

Despite advancements in science, researchers still face challenges in curing patients with
malignancies. This health issue is linked to various risk factors, including alcohol …

Alveolar Echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus
multilocularis, but its pathogenesis remains unclear. The primary objective of this study is to …

Immune evasion is a hallmark of persistent echinococcal infection, comprising modulation of
innate immune cells and antigen-specific T cell responses. However, recognition of …

Purpose: To validate the protective effect of a mammalian target of rapamycin (mTOR)
inhibitor on human retinal pigment epithelium (RPE) cells challenged with 7-ketocholesterol …