The advances in genetics and biochemistry that have taken place over the last 10 years led
to significant advances in experimental and clinical immunology. In turn, this has led to the …

Influenza viruses have perplexed scientists for over a hundred years. Yearly vaccines limit
their spread, but they do not prevent all infections. Therapeutic treatments for those …

COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …

Ectopic lymphoid structures form in a wide range of inflammatory conditions, including
infection, autoimmune disease, and cancer. In the context of infection, this response can be …

Background Microbiota integrity is essential for a growing number of physiological
processes. Consequently, disruption of microbiota homeostasis correlates with a variety of …

To better understand the systemic response to naturally acquired acute respiratory viral
infections, we prospectively enrolled 1610 healthy adults in 2009 and 2010. Of these, 142 …

Respiratory viral infections are a leading cause of disease and mortality. The severity of
these illnesses can vary markedly from mild or asymptomatic upper airway infections to …

Upon transit to colonization sites, bacteria often experience critical priming that prepares
them for subsequent, specific interactions with the host; however, the underlying …

The consequences of influenza virus infection are generally more severe in individuals over
65 years of age (the elderly). Immunosenescence enhances the susceptibility to viral …

Viral kinetic (VK) modeling has led to increased understanding of the within host dynamics
of viral infections and the effects of therapy. Here we review recent developments in the …