Multimodal brain and retinal imaging of dopaminergic degeneration in Parkinson disease

JY Lee, A Martin-Bastida, A Murueta-Goyena… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

Past, present and future role of retinal imaging in neurodegenerative disease

AH Kashani, S Asanad, JW Chan, MB Singer… - Progress in retinal and …, 2021 - Elsevier
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …

Retinal layers in Parkinson's disease: a meta-analysis of spectral-domain optical coherence tomography studies

A Chrysou, NM Jansonius, T van Laar - Parkinsonism & related disorders, 2019 - Elsevier
Abstract Background Patients with Parkinson's disease experience visual symptoms,
partially originating from retinal changes. Since 2011, multiple case-control studies using …

Retinal thinning associates with nigral dopaminergic loss in de novo Parkinson disease

J Ahn, JY Lee, TW Kim, EJ Yoon, S Oh, YK Kim… - Neurology, 2018 - AAN Enterprises
Objective To analyze the relationship between retinal thinning and nigral dopaminergic loss
in de novo Parkinson disease (PD). Methods Forty-nine patients with PD and 54 age …

Retinal α-synuclein deposits in Parkinson's disease patients and animal models

L Veys, M Vandenabeele, I Ortuno-Lizaran… - Acta …, 2019 - Springer
Despite decades of research, accurate diagnosis of Parkinson's disease remains a
challenge, and disease-modifying treatments are still lacking. Research into the early …

Central retina changes in Parkinson's disease: a systematic review and meta-analysis

L Huang, D Zhang, J Ji, Y Wang, R Zhang - Journal of neurology, 2021 - Springer
Background and purpose Central retina imaging is important for early Parkinson's disease
(PD) recognition. We aimed to investigate central retina changes using spectral domain …

Optical coherence tomography measurements as potential imaging biomarkers for Parkinson's disease: a systematic review and meta‐analysis

WC Zhou, JX Tao, J Li - European Journal of Neurology, 2021 - Wiley Online Library
Background and purpose Retinal pathological changes may precede or accompany the
deterioration of brain tissue in Parkinson's disease (PD). The purpose of this meta‐analysis …

[HTML][HTML] Measures of retinal structure and function as biomarkers in neurology and psychiatry

SM Silverstein, DL Demmin, JB Schallek… - Biomarkers in …, 2020 - Elsevier
Investigators have increasingly turned to studying the retina as a window into brain structure
and function. In neuropsychiatric diseases, retinal anatomy as assessed by optical …

Inner retinal thinning as a biomarker for cognitive impairment in de novo Parkinson's disease

MS Sung, SM Choi, J Kim, JY Ha, BC Kim, H Heo… - Scientific reports, 2019 - nature.com
We investigated the association between retinal changes measured using optical coherence
tomography (OCT) and diverse clinical grading scales in patients with Parkinson's disease …

Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases

A Murueta‐Goyena, R Del Pino, P Reyero… - Movement …, 2019 - Wiley Online Library
Background Retinal optical coherence tomography findings in Lewy body diseases and their
implications for visual outcomes remain controversial. We investigated whether region …