The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

The mechanisms responsible for perpetuation of human persistent atrial fibrillation (AF) are
controversial and probably vary between individuals. A wide spectrum of mechanisms have …

Over the past two decades percolation theory has been used to explain and model a wide
variety of phenomena that are of industrial and scientific importance. Examples include …

AF is a heterogeneous rhythm disorder that is related to a wide spectrum of etiologies and
has broad clinical presentations. Mechanisms underlying AF are complex and remain …

Background Complex fractionated atrial electrograms (CFAEs) have long been associated
with proarrhythmic alterations in atrial structure or electrophysiology. Structural alterations …

The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is
triggered by a periodic sequence of electrical waves (action potentials) originating in the …

Abstract Treatment of atrial fibrillation (AF), the most common arrhythmia in clinical practice,
remains challenging. Improved understanding of underlying mechanisms is needed to …

Maintenance of atrial fibrillation is a complex mechanism, including extensive electrical and
structural remodeling of the atria which involves progressive fibrogenesis. Galectin-3 is a …

In this work, we reported a computational study to quantitatively determine the individual
contributions of three candidate arrhythmic factors associated with Brugada Syndrome. In …

Background The Brugada pattern manifests as a spontaneous variability of the
electrocardiographic marker, suggesting a variability of the underlying electrical substrate …