Photo-/electrocatalytic functionalization of quinoxalin-2 (1H)-ones

K Sun, F Xiao, B Yu, WM He - Chinese Journal of Catalysis, 2021 - Elsevier
The photo-/electrocatalytic functionalization of quinoxalin-2 (1H)-ones has emerged as a
promising and powerful approach for post-synthetic modification of quinoxalin-2 (1H)-ones …

Dragging ras back in the ring

AG Stephen, D Esposito, RK Bagni, F McCormick - Cancer cell, 2014 - cell.com
Ras proteins play a major role in human cancers but have not yielded to therapeutic attack.
Ras-driven cancers are among the most difficult to treat and often excluded from therapies …

Ribosomal protein S6: a potential therapeutic target against cancer?

YW Yi, KS You, JS Park, SG Lee, YS Seong - International journal of …, 2021 - mdpi.com
Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

T Hart, KR Brown, F Sircoulomb, R Rottapel… - Molecular systems …, 2014 - embopress.org
Technological advancement has opened the door to systematic genetics in mammalian
cells. Genome‐scale loss‐of‐function screens can assay fitness defects induced by partial …

Electrochemically dehydrogenative C–H/P–H cross-coupling: effective synthesis of phosphonated quinoxalin-2 (1 H)-ones and xanthenes

KJ Li, YY Jiang, K Xu, CC Zeng, BG Sun - Green Chemistry, 2019 - pubs.rsc.org
An efficient electrochemical approach for the C (sp2)–H phosphonation of quinoxalin-2 (1H)-
ones and C (sp3)–H phosphonation of xanthenes has been developed. The chemistry was …

Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities

X Jiang, K Wu, R Bai, P Zhang, Y Zhang - European Journal of Medicinal …, 2022 - Elsevier
Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …

Three‐Component Reactions of Quinoxalin‐2(1H)‐ones: Recent Advances

KL Wang, HT Ji, LJ Ou, WM He - European Journal of Organic …, 2023 - Wiley Online Library
The multicomponent reactions of quinoxalin‐2 (1H)‐ones has attracted considerable interest
due to their significant biological and chemical activities. The very recent advances (from …

Photocatalyst-, metal-and additive-free, direct C–H arylation of quinoxalin-2 (1 H)-ones with aryl acyl peroxides induced by visible light

J Xu, H Zhang, J Zhao, Z Ni, P Zhang… - Organic Chemistry …, 2020 - pubs.rsc.org
A visible light-mediated direct C–H arylation of quinoxalin-2 (1H)-ones with aryl acyl
peroxides has been developed. The reaction proceeds smoothly through a radical process …

Visible-light-promoted direct C–H/S–H cross-coupling of quinoxalin-2 (1 H)-ones with thiols leading to 3-sulfenylated quinoxalin-2 (1 H)-ones in air

LY Xie, YL Chen, L Qin, Y Wen, JW Xie… - Organic Chemistry …, 2019 - pubs.rsc.org
A new and efficient visible-light-mediated strategy has been developed for the synthesis of 3-
sulfenylated quinoxalin-2 (1H)-ones via direct C–H sulfenylation of quinoxalin-2 (1H)-ones …

Transition-Metal-Free Direct C–H Arylation of Quinoxalin-2(1H)-ones with Diaryliodonium Salts at Room Temperature

K Yin, R Zhang - Organic letters, 2017 - ACS Publications
A method of synthesizing 3-arylquinoxalin-2 (1 H)-ones using diaryliodonium
tetrafluoroborates under mild conditions is described. This protocol has a wide substrate …