Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

The role of the immune system in autism spectrum disorder

A Meltzer, J Van de Water - Neuropsychopharmacology, 2017 - nature.com
Autism is a neurodevelopmental disorder characterized by deficits in communication and
social skills as well as repetitive and stereotypical behaviors. While much effort has focused …

Maternal immune activation and abnormal brain development across CNS disorders

I Knuesel, L Chicha, M Britschgi, SA Schobel… - Nature Reviews …, 2014 - nature.com
Epidemiological studies have shown a clear association between maternal infection and
schizophrenia or autism in the progeny. Animal models have revealed maternal immune …

Immune dysfunction and autoimmunity as pathological mechanisms in autism spectrum disorders

HK Hughes, E Mills Ko, D Rose… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorders (ASD) are a group of heterogeneous neurological disorders that
are highly variable and are clinically characterized by deficits in social interactions …

Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism

JT Morgan, G Chana, CA Pardo, C Achim… - Biological …, 2010 - Elsevier
BACKGROUND: In the neurodevelopmental disorder autism, several neuroimmune
abnormalities have been reported. However, it is unknown whether microglial somal volume …

Characterizing the interplay between autism spectrum disorder and comorbid medical conditions: An integrative review

C Tye, AK Runicles, AJO Whitehouse… - Frontiers in …, 2019 - frontiersin.org
Co-occurring medical disorders and associated physiological abnormalities in individuals
with autism spectrum disorder (ASD) may provide insight into causal pathways or underlying …

Modeling an autism risk factor in mice leads to permanent immune dysregulation

EY Hsiao, SW McBride, J Chow… - Proceedings of the …, 2012 - National Acad Sciences
Increasing evidence highlights a role for the immune system in the pathogenesis of autism
spectrum disorder (ASD), as immune dysregulation is observed in the brain, periphery, and …

Increased midgestational IFN-γ, IL-4 and IL-5 in women bearing a child with autism: a case-control study

PE Goines, LA Croen, D Braunschweig, CK Yoshida… - Molecular autism, 2011 - Springer
Background Immune anomalies have been documented in individuals with autism spectrum
disorders (ASDs) and their family members. It is unknown whether the maternal immune …

Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda

DL Coury, P Ashwood, A Fasano, G Fuchs… - …, 2012 - publications.aap.org
Autism spectrum disorders (ASDs) are a set of complex neurodevelopmental disorders
defined behaviorally by impaired social interaction, delayed and disordered language …

Genetic epidemiology and insights into interactive genetic and environmental effects in autism spectrum disorders

YS Kim, BL Leventhal - Biological psychiatry, 2015 - Elsevier
Understanding the pathogenesis of neurodevelopmental disorders has proven to be
challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental …