Phosphatidylserine (PS) is a major component of membrane bilayers whose change in
distribution between inner and outer leaflets is an important physiological signal. Normally …

Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

The calcium-activated chloride channel TMEM16A is a ligand-gated anion channel that
opens in response to an increase in intracellular Ca2+ concentration,,. The protein is …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

In all animal cells, phospholipids are asymmetrically distributed between the outer and inner
leaflets of the plasma membrane. This asymmetrical phospholipid distribution is disrupted in …

Systemic blood pressure is acutely controlled by total peripheral resistance as determined
by the diameter of small arteries and arterioles, the contractility of which is regulated by …

Asymmetrical distribution of phospholipids between the inner and outer plasma membrane
leaflets is disrupted in various biological processes. We recently identified TMEM16F, an …

The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

Frequent gene amplification of the receptor-activated calcium-dependent chloride channel
TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …