Purpose The B onferroni correction adjusts probability (p) values because of the increased
risk of a type I error when making multiple statistical tests. The routine use of this test has …

Multiplicity Considerations in Clinical Trials | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Scientists often adjust their significance threshold (alpha level) during null hypothesis
significance testing in order to take into account multiple testing and multiple comparisons …

Background The cancer-cell–killing property of atezolizumab may be enhanced by the
blockade of vascular endothelial growth factor–mediated immunosuppression with …

BACKGROUND: Most randomized controlled trials (RCTs) and meta-analyses of RCTs
examine effect modification (also called a subgroup effect or interaction), in which the effect …

Background The BCL2 inhibitor venetoclax has shown activity in patients with chronic
lymphocytic leukemia (CLL), but its efficacy in combination with other agents in patients with …

Transcranial direct current stimulation (tDCS) has been proposed as a new treatment in
major depressive disorder (MDD). This is a fully remote, multisite, double-blind, placebo …

It is well known that both the direction and magnitude of the treatment effect in clinical trials
are often affected by baseline patient characteristics (generally referred to as biomarkers) …

Background Multiple primary outcomes may be specified in randomised controlled trials
(RCTs). When analysing multiple outcomes it's important to control the family wise error rate …

This paper presents an overview of the current state of the art in multiple testing in genomics
data from a user's perspective. We describe methods for familywise error control, false …