Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Breakthroughs and applications of organ-on-a-chip technology

MC Koyilot, P Natarajan, CR Hunt, S Sivarajkumar… - Cells, 2022 - mdpi.com
Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …

Mechanical stimulation: a crucial element of organ-on-chip models

CL Thompson, S Fu, HK Heywood… - … in bioengineering and …, 2020 - frontiersin.org
Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

A lung/liver-on-a-chip platform for acute and chronic toxicity studies

D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar… - Lab on a Chip, 2018 - pubs.rsc.org
The merging of three-dimensional in vitro models with multi-organ-on-a-chip (MOC)
technology has taken in vitro assessment of chemicals to an unprecedented level. By …

Advances in smoking related in vitro inhalation toxicology: A perspective case of challenges and opportunities from progresses in lung-on-chip technologies

AV Singh, RS Maharjan, C Kromer, P Laux… - Chemical Research …, 2021 - ACS Publications
The inhalation toxicology of multifaceted particulate matter from the environment, cigarette
smoke, and e-cigarette liquid vapes is a major research topic concerning the adverse effect …

New generation of bioreactors that advance extracellular matrix modelling and tissue engineering

S Ahmed, VM Chauhan, AM Ghaemmaghami… - Biotechnology …, 2019 - Springer
Bioreactors hold a lot of promise for tissue engineering and regenerative medicine
applications. They have multiple uses including cell cultivation for therapeutic production …

Human-derived organ-on-a-chip for personalized drug development

YA Jodat, MG Kang, K Kiaee, GJ Kim… - Current …, 2018 - ingentaconnect.com
To reduce the required capital and time investment in the development of new
pharmaceutical agents, there is an urgent need for preclinical drug testing models that are …

[HTML][HTML] C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia

W Posch, J Vosper, A Noureen, V Zaderer… - Journal of Allergy and …, 2021 - Elsevier
Background Excessive inflammation triggered by a hitherto undescribed mechanism is a
hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and …

A dynamic perfusion based blood-brain barrier model for cytotoxicity testing and drug permeation

B Elbakary, RKS Badhan - Scientific Reports, 2020 - nature.com
The blood-brain barrier (BBB) serves to protect and regulate the CNS microenvironment.
The development of an in-vitro mimic of the BBB requires recapitulating the correct …

Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods

F Bayerl, DA Bejarano, G Bertacchi… - European Journal of …, 2023 - Wiley Online Library
This article is part of the Dendritic Cell Guidelines article series, which provides a collection
of state‐of‐the‐art protocols for the preparation, phenotype analysis by flow cytometry …