The Hsp90 chaperone network modulates Candida virulence traits

TR O'Meara, N Robbins, LE Cowen - Trends in microbiology, 2017 - cell.com
Hsp90 is a conserved molecular chaperone that facilitates the folding and function of client
proteins. Hsp90 function is dynamically regulated by interactions with co-chaperones and by …

Impact of the Environment upon the Candida albicans Cell Wall and Resultant Effects upon Immune Surveillance

DS Childers, GM Avelar, JM Bain, DE Larcombe… - The Fungal Cell Wall: An …, 2020 - Springer
The fungal cell wall is an essential organelle that maintains cellular morphology and
protects the fungus from environmental insults. For fungal pathogens such as Candida …

The defective gut colonization of Candida albicans hog1 MAPK mutants is restored by overexpressing the transcriptional regulator of the white opaque transition …

E Román, D Prieto, S Hidalgo-Vico, R Alonso-Monge… - Virulence, 2023 - Taylor & Francis
The transcriptional master regulator of the white opaque transition of Candida albicans
WOR1 is important for the adaptation to the commensal lifestyle in the mammalian gut, a …

Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner

AS Wagner, TJ Hancock, SW Lumsdaine… - PLoS …, 2021 - journals.plos.org
Masking the immunogenic cell wall epitope ß (1, 3)-glucan under an outer layer of
mannosylated glycoproteins is an important virulence factor deployed by Candida albicans …

Lrg1 regulates β (1, 3)-glucan masking in Candida albicans through the Cek1 MAP kinase pathway

T Chen, AS Wagner, RN Tams, JE Eyer, SJ Kauffman… - MBio, 2019 - Am Soc Microbiol
Candida albicans is among the most prevalent opportunistic human fungal pathogens. The
ability to mask the immunogenic polysaccharide β (1, 3)-glucan from immune detection via a …

[HTML][HTML] Accessibility and contribution to glucan masking of natural and genetically tagged versions of yeast wall protein 1 of Candida albicans

BL Granger - PloS one, 2018 - journals.plos.org
Yeast wall protein 1 (Ywp1) is an abundant glycoprotein of the cell wall of the yeast form of
Candida albicans, the most prevalent fungal pathogen of humans. Antibodies that bind to …

When Is It Appropriate to Take Off the Mask? Signaling Pathways That Regulate ß(1,3)-Glucan Exposure in Candida albicans

T Chen, AS Wagner, TB Reynolds - Frontiers in fungal biology, 2022 - frontiersin.org
Candida spp. are an important source of systemic and mucosal infections in immune
compromised populations. However, drug resistance or toxicity has put limits on the efficacy …

Cooperative Role of MAPK Pathways in the Interaction of Candida albicans with the Host Epithelium

I Correia, D Prieto, E Román, D Wilson, B Hube… - Microorganisms, 2019 - mdpi.com
Candida albicans is an important human fungal pathogen responsible for tens of millions of
infections as well as hundreds of thousands of severe life-threatening infections each year …

Revisiting the Vital Drivers and Mechanisms of β-Glucan Masking in Human Fungal Pathogen, Candida albicans

S Hameed, S Hans, S Singh, R Dhiman, R Monasky… - Pathogens, 2021 - mdpi.com
Among the several human fungal pathogens, Candida genus represents one of the most
implicated in the clinical scenario. There exist several distinctive features that govern the …

Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1, 4GlcNAc library

T Keenan, NE Hatton, J Porter, JB Vendeville… - Chemical …, 2023 - pubs.rsc.org
β-Mannosides are ubiquitous in nature, with diverse roles in many biological processes.
Notably, Manβ1, 4GlcNAc a constituent of the core N-glycan in eukaryotes was recently …